Simultaneous Estimation of Ofloxacin and Ornidazole in Synthetic Mixture by Q- Analysis UV-Spectrophotometric Method

Ofloxacin and ornidazole in combination are available as tablet dosage forms in the ratio of 2:5. A simple, reproducible and efficient method for the simultaneous determination of ofloxacin and ornidazole in synthetic mixture was developed. The proposed method is based on the Q-analysis UV Spectrophotometric method. The absorbance maxima of ofloxacin and ornidazole were found to be 286.2 nm and 319.2 nm, respectively in 5% methanol in distilled water. In Q-analysis, the isoabsorptive point for both the drugs was found at 294 nm. The linearity range lies between 1-15 μg/ml for ofloxacin and 1-30 μg/ml for ornidazole at their respective wavelengths. Both the drugs obey Beer’s law. The recovery studies confirmed the accuracy of the proposed methods.